Background: Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and\n23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoriasis\nand psoriatic arthritis treatment and has been successfully evaluated in phase II and III trials for patients with Crohn�s\ndisease (CD).\nCase presentation: We report here the case of a patient who became pregnant during treatment with ustekinumab\nfor a refractory CD and which ended in miscarriage.\nConclusion: Ustekinumab is a relatively new pharmacotherapy and in addition to this clinical case, we reviewed the\npublished literature concerning the use of this treatment during pregnancy and its consequences on pregnancy and\nfetus outcome.
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